Homeostasis

GAPDH Inhibits Intracellular Pathways during Starvation for Cellular Energy Homeostasis

Starvation poses a fundamental challenge to cell survival. Whereas the role of autophagy in promoting energy homeostasis in this setting has been extensively characterized(1), other mechanisms are less well understood. Here we reveal that …

Pyridine Dinucleotides from Molecules to Man

SIGNIFICANCE: Pyridine dinucleotides, nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), were discovered more than 100 years ago as necessary cofactors for fermentation in yeast extracts. Since that time, …