Malate Dehydrogenase/*metabolism

Hypoxia-Mediated Increases in L-2-Hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress

Metabolic adaptation to hypoxia is critical for survival in metazoan species for which reason they have developed cellular mechanisms for mitigating its adverse consequences. Here, we have identified L-2-hydroxyglutarate (L2HG) as a universal …