Reactive Oxygen Species/metabolism

Systems Biology Approaches to Redox Metabolism in Stress and Disease States

SIGNIFICANCE: All cellular metabolic processes are tied to the cellular redox environment. Therefore, maintaining redox homeostasis is critically important for normal cell function. Indeed, redox stress contributes to the pathobiology of many human …

Pyridine Dinucleotides from Molecules to Man

SIGNIFICANCE: Pyridine dinucleotides, nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), were discovered more than 100 years ago as necessary cofactors for fermentation in yeast extracts. Since that time, …