*systems biology

Systems Biology Approaches to Redox Metabolism in Stress and Disease States

SIGNIFICANCE: All cellular metabolic processes are tied to the cellular redox environment. Therefore, maintaining redox homeostasis is critically important for normal cell function. Indeed, redox stress contributes to the pathobiology of many human …

NEDD9 Targets COL3A1 to Promote Endothelial Fibrosis and Pulmonary Arterial Hypertension

Germline mutations involving small mothers against decapentaplegic-transforming growth factor-beta (SMAD-TGF-beta) signaling are an important but rare cause of pulmonary arterial hypertension (PAH), which is a disease characterized, in part, by …

Network Analysis to Risk Stratify Patients With Exercise Intolerance

RATIONALE: Current methods assessing clinical risk because of exercise intolerance in patients with cardiopulmonary disease rely on a small subset of traditional variables. Alternative strategies incorporating the spectrum of factors underlying …