Metabolic reprogramming in pulmonary vascular and fibrotic lung disease
The Oldham Lab investigates how cellular metabolic reprogramming contributes to pulmonary hypertension and pulmonary fibrosis. By improving our understanding of cell metabolism, we aim to develop new therapeutic strategies for the treatment of lung disease.
We study in vitro and in vivo model systems with state-of-the-art analytical techniques, including metabolomics, stable isotope tracing, extracellular flux analysis, systems biology, and network medicine. The lab is part of the Division of Pulmonary, Critical Care and Sleep Medicine at The Warren Alpert Medical School of Brown University and Brown University Health.
Research
The lab
-
William Oldham
Principal Investigator
- Hilaire Lam Research Scientist
- Navneet Singh Physician-Scientist
- Aseel Khalil Graduate Student
-
Diana Ferreyra Faustino
Graduate Student
- Jacob Nipoti Research Assistant
News
Jacob Nipoti joins the lab as a research assistant, arriving from the University of New Hampshire.
Navneet Singh joins the lab. He is Assistant Professor of Medicine and studies the liver–lung axis in pulmonary arterial hypertension.
The lab's work on lactate transport in pulmonary fibrosis is published in Science Translational Medicine, and selected for a research highlight in Nature Reviews Drug Discovery.